	   SnapGene      ,GCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCgccaccatggtgagcaagggcgaggagctgttcaccggggtggtgcccatcctggtcgagctggacggcgacgtaaacggccacaagttcagcgtgtccggcgagggcgagggcgatgccacctacggcaagctgaccctgaagttcatctgcaccaccggcaagctgcccgtgccctggcccaccctcgtgaccaccctgacctacggcgtgcagtgcttcagccgctaccccgaccacatgaagcagcacgacttcttcaagtccgccatgcccgaaggctacgtccaggagcgcaccatcttcttcaaggacgacggcaactacaagacccgcgccgaggtgaagttcgagggcgacaccctggtgaaccgcatcgagctgaagggcatcgacttcaaggaggacggcaacatcctggggcacaagctggagtacaactacaacagccacaacgtctatatcatggccgacaagcagaagaacggcatcaaggtgaacttcaagatccgccacaacatcgaggacggcagcgtgcagctcgccgaccactaccagcagaacacccccatcggcgacggccccgtgctgctgcccgacaaccactacctgagcacccagtccgccctgagcaaagaccccaacgagaagcgcgatcacatggtcctgctggagttcgtgaccgccgccgggatcactctcggcatggacgagctgtacaaggGaGGCGGAGGTAGTGGAGGAGGGGGAAGCggaggcggagggagtGAATTCGGTACCGAGCTCaagcttCACCACCACCACCACCACTGAGGATCCtGATATCCAGCACAGTGGCGGCCGCTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  6Y                                       +      (      "            "                                                                     "                        "   %            ,      !   *   !   !      )            "            
                  %   #               !      /                                                                                                                                           $            !                        &      	                                                                           '                                                                             '                   
               $   0            (   #                     %               $   #      !      
                                           2   "         %   "               %      '         ñ y‡KLghins‚ƒ¤ÒÛÜ€�ªRRÔò_á’Îà yzœ¸úN5M]„�¥Q	ó
16J·Õ2`âß·‡&‘^ – ò �ˆjoÝŽÀ­	X¨Só“8¦á · `ætËÑÄåºt¯Ó‚Ós«FSï£u'‹çÏf C “�ûOz…ô6<EHTZ^…üÊ
Ö
ô
\âaˆ N=ŽÄ$	œ	³	û	2è~ªÜ3í˜à£ã'ÀG_o f{�ˆ¦R		!<XäýN‘ÃÖãÅžr¸Ó’ß¹ z¹¡š÷o&y	ã7±½K¸z �D÷k‰Œ¸ÐQWkp¬Á®	ö	YÏ{©ôi¸ÎlH9 $žåê?iÞ	³ÈXr—­ô!B — Lm�Ççj	H³TŸRiÐH”É§â F ó þ˜ù;	ïžž”¿øÖ+ œ açîu¥ÆÌÒ2Å 9W¦Áõ¬G–9Ia®åè“fv¬Å+l‹èµ¤p†Ðg o ®õR©á¡æûIs!uœ¤Ë	
téTŠ0:dK( t 40\z°¸Ôgƒ¿	
‚
Í
ß
ai„�ñú<ˆ™¬2¤Éð¤¿¦9(ÜŒÁ„ ¸ +ì±6¦©»Ôb	Ÿ
¥
Ù
Pþ… TÑ˜èó" D üxÉÏ¶Âõm7=FIU[Ž¸;†¿�
£
È
Ë
×
_çLdg«8‰ Pè]w~bÅ±aï M ”ž_±Rý<ãþgÁ/§Kw X n{œ†ÝÆØ*ou	µ
õ
ÔØßF�×¯úJ§ì<µ" ˆ ïUw»âBêO�Ï	
À
,3Jé
ÜÝ™áÉæ{ôäó(éH™ 8>Å´	ü	yÇY›³4îoj¨ÁÓpÐö ‹ c�	�	×rë«OÛc`xÅ  ÓET“É%	3Û%ò4é¤©  ° GÕ§Ä9�ŒåþdÄ7û ½ g—àÓä„Æy‚©“º Ï |‰•»H	S	\	z	/=’€†Ÿ_¹ÇÈ ]ñ‘Í
"Y§øOÇ×+s~†ÔàIž°Þàñ Q]†Ùâ“Ý¢¨›žøp£'äöä F9j¹GZ™
 } É È:¸z’}¾vw j Ö {rºC_ì×	†
o8šL�{|iD y 8CRé"+M¬…ß¬ÂÆ¼Z²ô^b�µF³s ‘døŠC¤lq­
Ñ	š	±	ù	Zø|ž¬PjæÌÏ¡öj El ¹ÑR	aÂÆ
XÑ± ø6BI: < > »ñÀX¡	£	¯	÷	–ª¯ç,tmúh R �5:y¬Û›ÐM õ>¤.¹Ÿ½´	û O ë@TðÎÃ
ÿ²"Cv5 å %mŸæÊ«–éÉYs˜1ì3þ + `–½-ßÒ	
û
}
gwp´®îõ	€jÉ 	 ³ ²Ë#Vó/jÞM @ Æ åóù#Æ M%b RUºâðyìu " ˜ Û k	©	¹Ñ²$@©Êü	¨ Ÿ Mn ¤Àöè&°úS¨j.ŽIQ÷G{2" û d€¹ò¾`�È		k
I˜´*>Uå¢°=ÃW8•Ç÷ã G Ç™õU~/;Ÿqx ô T‰Ü3–Zq¥	ë	3
¡½&aŸcÀoå'Y‰ …ÿ+³N<	ðsb•N® Âj€Ïú)ÿ¸	 
@
ËWÍiù× Jkè:RX§ªÂóï/”—¯æHÒ]gª±Æ¶FÇn· V ® v¦ÇÍÓÆ¡ï�	HÅÖJbéh­m©G¯¥qÑh � Ä bï¾3w	Ä”n#,Œä‡0" T ¤ aˆ±íéöÿ/7¥­í:< Ð[w˜¦éMûeîKœè% ¯ S	7X?t{�v™È	Ì	

š
E§àêUê‹Ž¤Y\gð÷¦ Z p àpâ¢üÚ~Ö	ï	
7
æ
�ü1U¤ÑþM¿>LV  „ öØçJ"DI�øÛ	ß	#
'
+�Ï>" 7EàGLeœ   ªú[Š	ÈŸ¥AuÚ0;ê, J ¦ 5Y}žæß®±ÿ,Ê¡Ïw	ƒ
…žû=‰š¥ÙñÀß¥D•§(ü$)J?¡é e 9]E{"·
bjò@­¶Ê‰»Ý+^! 8 u ‘ © )1<w¹Fh�Î
à
÷
T£k‰áø¥�'�¾ë-�…:*  1 ~q­±Õ=v„À	
í
ˆn3Ày‰šº:]œ¨öý%œºÂt�Î|¶!  B³7‚ªdY	 
¦
Q�“Otì"o†¡�¼Ù »àé#ôS! ' ¹ rÆc²Øn#bèì+[Õÿ.v@U„‘Ü<X,žý 0ñÒÝc	©
¯
Ú
g'1’î÷ÑOÒe
) ,<J¦ÏíýÕ�
s§´Ó¼úë19ÛïE
Q
Z
f
p
{
¯Ò´Bmì#?B™‚ • xMsÊÐÃä4J\¹�Ú�¿P	¬	©5à¶Šæ]e¥ß y„™óönG�<x‡É
 âWüM¼ìy�qÒÞF E ý·P>Võ	Gžh¬" n s › íy8V›À¾	Ê	

ž
¤
Ì
Ø
Þ
`è18eÄ8Š´9c£J ·œ
^ÞŒcf¦À. Š AD’éÈÎ	
¿
xÚñåèizòèb¨Ï ¼ \8ƒ^}ÆßxÇ6ð
 Q«Þ‘ã|Áv² Q º9B`£šÐ	Å
LæÿË 5žõùg³ú  * N ä l•±Ê"USÑ	
Â
|í04ëL ! Ú ú Ÿ¸ñ½ä¨	j
=äL
Âö#a7?F¨ïxö 2„iÎ²þ·	ê	ÿ	2
?
.bhX j`½‡vìQòþ.6¤ì.ÄÕÃGgÏ°ã¨EFíÆ/¶% Y oWZ>�ÇÙž}˜Ç	Ú	î	
"
6
Ù6ßûK�£X[Ð¥=›# d X|�åÞ}+pvÎuv	¶
ì
ö
àˆŽ¤C¹›õ#$*ŽÍ & A"Ñëë!ØíA�Ûß m r rx˜ãòO3€O	47�Ã pµÑå¢ÝI\d ‰ ªC[Ý�Ç7ÀÝð‚uçy|5 ¹Éƒ·ðh¼¶	Ð	þ	
Á
K{åaÊõô3êîW²ù! % c WäV=ëPuýtÙ	!
ë
-Ãêf5Þìšâ"W)Åš ÜÆµ	Ø	ý	 
ê
zœ4äëÂïÿ
�oÐÄ±[ø/ \ ¯Â6²³´n	o	p	‚	ƒ	è
é
€þ	STklmn©ÎÏîïÁÂÃ°ÂÔ@ANXYZÑÒ÷ ] 'è°Ãâ97?{q	„	�Z'0´UéðüOqÓÛ ¡­Äµ	È[5p37ªÖÃÕB× (ZŒßé]™Äã8r	ž	Ø‘‚ì[
dûLñ*¦PrÆ á Wu>3•	s1ËÓCdŒ–ay�ÔÜ ^ € ë :d@…	�	”	æ	.
Š
(µÆê  Œ ç ±|€¬˜PÜVý1 @oµ®(FåŠ	Xç¥O›Ä j Ìþg”&	)		4yÉÐóšê4CØ ¢Ï¤U¶ 	K
`
Ü&õ\[Ö«| ªÖ !Ô»ÅÊ0	ñ	9
q6q5m8×S  
)�êB^šäi4÷$¶Å€
:†æ_yƒíœ‚& † [àS9s	-mÙÿ\™ÅüMÃò§®³ ± bÅŸ	eqö°¸üsÇ  ÄûHÖqŸ¨Ô	Ý	
%
˜
Ž�’@eÝ+*8lQ  â ÿ jvhK–á	=
Á¢6ó_De£Ý X4M	2âåzÔ”bÕ ¾ Â/˜ý
tÔ‘¿ À ?ŸyÓÌ…Çƒª�—z€» � Ì Ó NƒÖ�ÚAKŠg	0>CÖþ¶r[½–« Ð Þ ì ÷ ø/<;ú¼‘	ç	/
I `Èë“ _ ˜}–I	T	]	{	†	‹
”
�)9ðºRÉžÁËî e]b@	•	t
º
e¸“‡GÇŠ\ 65Úéj�F}Ø#�õÌÑ—$.­QW_�gß  è ¶¿Z²1LòÎƒùv¹y"an™¶ÝNËþ2ÍŸÿº¢  - � 'ö�ï6	á	)
ZdPØi÷t‡ÕAJ”á “^’šáU
ÿ
¨È¼ÔT,á[±/ò µ ï "œãw¶õ£¯ß0ŸùGq¤¢åGÎÚ�…�m AA]œæ(å:|ÕH2z¦€œ R^‡Ú+”©~)^Ì÷	!Ü°PÅ Â pÍÞç‹	C¡kºYè[úcš¸r  ¡{zØw›¾ë!aD  h k ~ Íµ¨&;e¹1“'	€	5w~%.ÄÎQ5Ù Ê ´%XQÿhõÊ¿Ñô¬¡½ì É•%*	Ìxàk £&-‹Ø&!	pÝ)9'›B �‡”$E × H¥‰¿‡
|\×â} |ª»`íV'·ö}«&  sÐD 	,	L
a
àM]‘¾¬jO×|‚ z 9„ÿÕlÃ³õ_Œ{ÂG<¬¾t™æ ?¬fü#NŒ†Œ¼|‚…ˆËò	:
½Àc‡9'‘ØT, 	Û,Â§Çi°r‚7ÉÛ=  D‹"Sê&H­Ë—ÊàÆ­1	[Íðr¶6n´ Ž_›åùfmrŒ£®ÑÒWrE§îQ¢ñt&7 B ’e %Dû	#	›	²	ú	Õ
;[ç}�Âá—¢¿ Cj‹—ÏøÆi	zQ�–Íó A¾÷k~G'$ *3­ëôQ¨/[5¥·�
ùý;‡`„Ÿ­Èä’*kç‰Ð—ƒò L mÅ×�:Q¾t	´
Ç
EýùfÄ7J`î;´ ‡ îTºÒáSb2ÖÚ+Ûš²NÈów˜Ä  Î F–ÌºÃßG	y	.Œ‹¦ ÒÆ*…¨¯! x È Õ 7P\…Øáq’Üè!*
õ…
nYó8]�F˜hC ; = Ú	™	 	¢	°	ø	�«O®°÷+-¼A ² ¼ò.ïú
fvèþ±uiýÈ ? c£òõ	—)ù§¸¯PT¹ûët ÆÁ(MY¤	 ¼Ê%`ôVr:ÌMnä&­ S £ I©“m—©¥LúJm ƒ ù6zCÕ	Þ	
&
™
å
@ßŽœ DF/T£ý¾
  0 7 � ¨ (;­°þ œ‡?mjØÞ'º, ]9{µ&  ¥ÅüŽ×	r³Üçù*X	®
�ÑNs³Afnuö"?ºd"W+�Rü ” š wìLUÙŒ¾«	Ý
7 ³Þ	 ¶â‹äÞw-Î   P Ù ã ù k1Aã™Ï	é	1
>
Ä
K`6Ef  i_—ñ5Â‡£ô¢#DÌ¤ $ b üN	t´2í4c & ç¬Ã5zm	3ãê€èíûÕ¯Ö à æ Y=2	“	‰
	—úKÊ0B• nË~	‰	J
_
æZ™Õ{ÿ 	aÃúµÓ	
—
l˜¯�k% ¿ J.L	ü
x~
 Ò Ý —Õ.;a?	f	“
¹
dBÕýqïQ’•ªÀÊ , ¾40™à5	þ
ô~u¸-hm»µÓS^€öÊ@Ìþ¡ ´ Á î !›Ì*ô@Þ/}¡ ÔÍÙb�„Ž 
 g ³$W§0$½ß`«¼ ,ß#N%{� >G‹Ák¯Ìz†ÁÈ&�«˜å A ¬P§‹úh	Ô
VDÇã¡‘sò½}ñ¾ w Ç Í Ô O„×p‘Û¹ôF	1¥7eÇ)„ív—Ã : ¢ôL	ù
»$óøNU·OS»ã¬ ‚ ¢ æøB)W	ä
?lm×ÿl&Sc!IV\z€ “ ™ ø 0‹˜½ª	è	0
¡ËÍ # a ß <Âû
	l	}	ˆ	’	J³çìú/A® Ñ Ü ù3K	’
–
ülºÒRÉËý
” © í  š=+ Àa%�ª"ä$ ¡ Oo¡¦÷óE	V	Ó
ã
ºTkñNRƒ¼H|Â ` ™ÁŠ—Ÿ		J	|	‡	‘
•
ûæùÊ­#ŸÌ'   N¥éêD	U	Œ
�
Ž
�
�
Ð
Ñ
Ò
â
¸¹‹±:;<=/0JKLMŠ»åø<"Š‹ ~~½-BHUjë^	'Œ‚²*>©)1�Ôí‹S=(3Œï « ¿fCaì_	(f¹+Vƒ§é£ÜT9ÓËø ü �ºó>e•ïXyÉ”+?>ØX‡‹)� b’à^c»IV	A	–	u
Jµ�*4?B•æHÕîÄŒ>]È4  e¾
.LQk‘	l
»
™úˆ³ªÈ*}ƒ2�±–†äð žg~9	`	g‚â¨0Rœ¤ÝÔÌ 6šÀÛêk¯ÕªºÒö˜W„Xù È$öSVþ®< ¢`Urhvyà H ¬ 7€GDYbÙí)Í,%/ê‡“‚:  »?Ï¦	ì	4
¢úº·Þd?ž3DÎŒæ£  é UŠ·Ý[—³f–ðMYsr.	ä	,
¾5bÀ_wÌÿ QŠÛŽ õ ý À4ô2[b„w•Û_oš ñÁYˆ(Z¸»~± uF‚ózÊ'gz#,@Â
‹¼Oø®Ù¼p *   . Ž ÷ðOd¼—	¬
²
ŠŽCOtøÿ–K•?^5 ( ,´á_³×x=	+–I…�O c�“J		B	¶ñ5@çj{cÅ'ˆÖ ~Éâ „  †W7	â	*
v
K[eQÙªÖïuBÙ¯ ÒÃk_Ð’N
c
m
x
MšÌ©´½~<²ÎU-‘Û0å €€ˆ¿�› 		¼
 €‰ÌXÉ+Õ3j\Äó ”û“*/?R]pûÉ«„¬€âúÐØ‡ 3 fÿ"âMl†¹	Â	


A
V
ï
‘žØl—²ñ  ¶ ð x·†ò
0QI¶Ó1^Þ‘†%�Í ;SYÃã°©ÛÄân¸ #�äKléöh«æ:	²Îîh�²ÇÏWq·G“ÈÕ' ¤°Åà1 úHrŸ¥ ¨ôf£a	Ohƒœð•˜«H£ç¾S¥«Û/Ào… W w›ÈÎµÁÜlç)n°¢
ævÓ×K;}Ö®Iª°ë¦v 7vŽ	IÆ	$qêXn3§Òõ ¯ Ôð”[	÷c…H��Ýú  | BB§L^�Çë9„¢·Ö«Å»E™ai€Yu´E{ri	 cð¿4x«•÷WÐÿ=£åsi
 _,ÉªÍÝ•o2 ž Å ¿_ø	%
"Å¯¡$-�<±VQzáÆ1 SˆÛ•*pT}apwˆ U ­ Ã °îè Œ	î;ÑZ\"d®›ç  ß‰×H÷*D¦Î=!éfïLöUé$ I ¥ 8D¬É!<ES¢ˆµ÷¿&x€ˆ”™\§½êûIü>›¹sè0 /;IqÎðÔbm²a�Òê08ZcÚîD
P
Y
e
o
z
¨
’®-&0lŽ‘»ë>ÐNƒ	;� ƒwš½	É	ô	

F¨áVû0»ßëx‰œbE¤ » 
@‘Í	
›
¾
{Ùe¥¿]hÆñç§  ) ° !T8Í¢§	i
-	ì
Ÿ"4�>øõ( ¼@Y!u|Ž�Ðê|Í-Æ	í	
5
£ë ÎB¸@Œ�ZEÏÚÞ�.# l q ¸È‚Vq¶ãg—©ñ<NZ2ts6¿Â6e`!Vx¡VÜ [ ®ÁáÛ±	�	×	
ç
&/ZÁýR26ÍÀ?MWÚ   ê Vt‹Þ\˜”å	-
�cÅ )¥Ò‹� i ?´Î£ý'fºä(	/	ð	8
xpôÏWlÿNšR … AhRp3ö#žÜ	$

,…?^xÜp›õÂ­·)²  þ iÁ<
žÀ¡Òá5ò^¢¾ Ë ö M‚÷�ÙJ\ùs
·8FHZ‰[¼�í% µ&5Y’õŽÙè KiœîE×à	(
T
c‚ËÐ–#x!`MZ“f.¹ v\æ]Ë	BÛ{ù1y¯·ql ´P
%dô v$-ÃËÍ×P ë  ©%Gˆ¾Š%&+	(AŒ½†“á Š«eƒÚûþ%‹Ê–É{~�„‡¦h¿‹ï;Ú<½+ÿ$ 2ó.Z–ŸÎ e¢Ð"	qü:�¦PÁàð)–%ˆ•@–F6#  K 6çí)àÄÖŒ•ËP½Þx	„
³
‹Õ*ŠÚòDŽE—g_ ~-Ùñ'î˜	ŸÉ_(œu¦­9®Ëý*L%@ê!  / 6 � § ¤'ø¯²ý­
†Þ>r›²itC!E–¨¹Kù ¢ü Ø ^µâØ4Ü
J†ŠãÝ,
 1yI
^
ˆ
ùÔ Ô:I-`´4	>	e	¸
ckóA·,—}]?P$ f )Ý.F|¦ŠÀ#®Ë¼ØÞŽ~_ 9 v «(¸	ø
Uk¤òlâ6÷�dÆ( ’ *2k¿Q~.Ž!ã }¼,AGTi‰žò	C	Ï
á
·Š(Óì‚‰ä;¬!'‰ ª =ad‘”îWxß	ºKPù)3A”¦è|‚Û×†ÒÊ… ®ÔX©8	áRý†’›¡u   tEr-	ã	+
f4Ú^Á	Š»¿^ð÷v�­C»P·Ú}°   ²Öw	«
±
‰N„z©þ&}Øƒ 2 ‡Ñþ!>…Á		
M
b
w
î
L\oË;�«×kÃ�ÏÚ …Ä eñ
N›±ÍPªí¢µ½ÚÃVp.¿á$’„ { Ku´8ƒ¶m“Z	¡
Äu#Dp`t³DêÜuô ª¾o”Ï|;o12  .:HïÓCl¯Ö`Ñ«È ;C
O
X
d
n
y
§
R‘‡´ö��¾%!=¼ÏH=­õšçTæ" ( º ÿ‚�ÌœéÌ,¼	Å	ó	

h
½
/Í,Aˆ	œÅÙÝ=ô- >sÇ�­ÀUã°	ÁdoóYV k(™U Lh�@ŽØg‘o�›íÖ;
S
r
~
�¶]w4]’Y¶-% ¨‰$d³Ùý$O$c‡½}€ƒ†‰$å\	 ¾ŠîÊÖ…’:¶Ÿþ" 5 1ò•ì(ÍÃÕü”íÝÈÔ^q±hs¬ï8D•­¸Êfû ÓÜ-033	d	H
]
Û
øÓÜ># 
Þ+@OSˆñj(2“ÒÚP�ãÑˆ Óý¨ª
°
üÊƒ… Ù -GîJt®©µ½Ç:nB
W
ð
°CÎ$s:Conƒó% =Kg§þ�×#T�šËâ#ä¯»	Ä	

R
g
q
}
µ\níò›µ˜µ 4 Òë'ÌÔüì2N‡Üð2	G
\
ÓC”Ÿ·Ù"' EFÐÑŒÖI˜™¨áû ãm®º	Ã	

F
[
|
ñ@AB’“789mš³´ò!  ,Ð  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                            (                                                                                                                                                      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             	            	                	                             	                        	                                                                                                                                                                                   &                                                                                                                                                                   
                  
                              /               
            	                  
         	               	                                                2         #   "                  t   M               "      T                                                                                                                                                                       (                                                                      
                                                                                                                                                                                                                             	    	      	             	        	                                                                 &                                                         
      
          /     
    	      
   	     	                2   # "      t M     "  T   l7  m1  mK  mq  qq  uµ  {wöÂZË¯ì2	y
”´ÍV¼ÓieƒÊÌ	
ü) � �	ÁÎrF,¦íà £
FüaÖ	
� ,¦ÆíJb¾ú3<¡¹öø"=[Ö	
Q
 
¦
žò	”š3bmîn±#\àœ\OêYi³RYwiYiYY
AeƒÊK^fl¼	
¤x¶ýïŠŠ§‘øY'À­ÃÕ‘ y
Ü°ò	¹
Û{Ô�´�K	Ø
Q†Ù“w~J°rEiL©Œi¤¬Ïô:«;¾F¯µOÄ°5¨Oý„ŸSò] c„	'íà*Ú=Q†Ù“¬j¹†Â ô× ÆoØ.´	).	)®ð
ºÞ ;‘	IÛ
V]�ºsÐ.	)ý�oº¯Ó‚{ý¡¬��Û	#
>ß}Å¹ÌpþËg
›IîÞý¼_`.6¬vè©Œ¦i�ºƒ�¤¿	
¬Ïô9:˜Á”â àËÃdr4^vÚÝP±*ËÛ@g…´Ì»	
~
¡
Û
ð
P]ï”EÌÂU‘�¤Zÿdì¡¼¾:xFÈ
¨OÄ	
¡Ï¥$5yø¨O�EÝr@g~
]¬ �Æoº¯Ó‚sÐØ.´	).Á±ôw@g~
Û
]zƒ
ÜV ,íY]â3w~è™�+9dÈ	Û	
#
AûÖ:>gk¡¼#@­(UÜ@g~
]�Û	#
>ô*\�	XNÖr}Óßßð® Ób5E×Ë#7÷%Að
Áæù­9WÁ®Òk_ÐN
c
m
x
<Îo—íà *Úà=ËÃŽÆ	
ŒZ¯ý cÝ	%
ÁÆ ~uÆ Ÿñ€«ÑRÈÿ	w~.	)¬ Y“´¼
¾úVŽº5z0ÝcÅ'wÁÄ± Â ²j@ ùd¡¼ÈÍBH=ç³ 
té®ÞÍB~r®4^dvÚ�öy Â^sÉ9	œÔŽW§7 ±"U.L[i	È´�	!XNÖrÓß]‘§Ç+~à°ñ1ò•‚Í¼	ó	
/ïˆ•…®P±¦ Xt{®±…ê=šD•§J‹ŽY¡· +ì¦ùº»Ó±˜çøÖ…ð
ñ
°Pµo$ƒDk¸ÐQÁH9‚zgÙ¼*ù±øÖXt{ê‹ŽY¦ ®±…=šD•§J¡‘�›íÖS
�w’-Ä9å£¯ß0ŸùGq¤¢GÚ“ ¦ BXt{®±§ªó¦
Q…�êï=”—š†æ�D•§ª »J‹ŽY¡ônS1ò…•‚Í¼	ó	
ð
ñ
°P/µïˆ•o$ƒØçJDß	'
Ï" Le GÕ§�Œd7-!	p9‡”E( ÿÌh
,	œ=ô¦äýÃ’ T
Z. �CK ÄÖŒP½³
D_y¸6J·¸	 
@
"œãõ¡Ø&å'›{Îë!$ K ’ ÄÖŒP½³
D�C_8¢Ÿ4�ø%Š%(AŒ†“Ýj¹Z™‡-Gî®Ç:B
W
$/HÒ]‹ rC±ý	’L†«O�Ûgi§�¢ETi}Ypw	 O¼’²
ŠâC¨d²–Ûæ^ÞO(2“ÚÑwâ3äHmÊ 	&XY˜$o©Bþˆ B�
Üæ{c�“J@ç{ÖÉ„±ýgrC	L�i 	&XoB‹ ’†«OÛ B§ªó¦
Q�ï”—†æ�ª »ônS%8Š¢%(AŒ†“Ÿ4�ø† SÙ™Mòü ó”X‡m0U ­ Ã °îè Œ	î;ÑZ\"d®›ç .:HïÓCl¯Ö`Ñ«È ;C
O
X
d
n
y
§
R‘‡´ö��¾%!=¼ÏH=­õšçTæJkè:RX§ªÂóï/”—¯æHÒ]gª±Æ¶FÇn·	 ³ ²Ë#Vó/jÞMd X|�åÞ}+pvÎuv	¶
ì
ö
àˆŽ¤C¹›õ#$*ŽÍT ¤ aˆ±íéöÿ/7¥­í:< Ð[w˜¦éMûeîKœèØ ^µâØ4Ü
J†ŠãÝ,]ñ‘Í
"Y§øOÇ×+s~†ÔàIž°Þàñ¸ +ì±6¦©»Ôb	Ÿ
¥
Ù
Pþ… TÑ˜èó…Ä eñ
N›±ÍPªí¢µ½ÚÃVp.¿á$’„… AhRp3ö#žÜ	$

,…?^xÜp›õÂ­·)²& d t ¸ +4ì0X\|�±åAzÞ"6}¦+pv©»Ñë°¸ÎÔguƒÔb	v	¿	
‚
Ÿ
¥
¶
Í
Ù
ß
ì
ö
Pai„�ñúþ<ˆ™¬ë!2… ¤Éàð¤¿ˆŽ¤ØíCT¦¹9›õ#(A�ÑÜ$Œ˜ÁÛßè*„ŽÍó … ¿ þ 	aiÁÃúAJhRp.3ö#žµL	Ó	Ü	
$
<

—
ü
,l…ž?^xÀ˜Üpx›¡Òáõ5~ò¯Â
^�­·)k¢²¾%R^‡Ú+”©~)^Ì÷	!Ü°PÅƒ ù6zCÕ	Þ	
&
™
å
@ßŽœ DF/T£ý¾
*^ € ë :d@…	�	”	æ	.
Š
(µÆêÓý¨ª
°
üÊƒ… ÙD üxÉÏ¶Âõm7=FIU[Ž¸;†¿�
£
È
Ë
×
_çLdg«8‰# a ß <Âû
	l	}	ˆ	’	J³çìú/A®E d R^‡Ú	+”ýX|�©Ûå,~·Þ)P}Â+>pvVÎ^u§Ì÷	v	õ	¶
ì
ö
GÇ!i°Üàrž‚ˆŽ¤7C¹h›Éõ#¬$°Û=*PŽÍÅ 6šÀÛêk¯ÕªºÒö˜W„Xù   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  #	<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="0" name="EGFP" directionality="1" translationMW="26941.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="1680" maxFusedRunOn="1680"><Segment range="874-876" color="#05fd14" type="standard" translated="1"/><Segment name="1a" range="877-879" color="#05fd14" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="880-1590" color="#05fd14" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="M,V,SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITLGMDELYK"/></Q></Feature><Feature recentID="1" name="Linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1680" maxFusedRunOn="1680"><Segment range="1591-1605" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGS"/></Q></Feature><Feature recentID="2" name="Linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1680" maxFusedRunOn="1680"><Segment range="1606-1620" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGS"/></Q></Feature><Feature recentID="3" name="Kozak" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="868-877" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="4" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5949" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5158-5949" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5950-6018" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="5" name="G418" directionality="1" translationMW="29047.90" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2862-3656" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="6" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4402-4987" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2024-2452" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2466-2795" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1754-1978" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2646-2781" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3830-3951" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6019-6123" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="Linker" directionality="1" translationMW="333.30" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1680" maxFusedRunOn="1680"><Segment range="1621-1635" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGS"/></Q></Feature><Feature recentID="17" name="6xHis" directionality="1" translationMW="840.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1680" maxFusedRunOn="1680" detectionMode="exactProteinMatch"><Segment range="1660-1677" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;6xHis affinity tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="HHHHHH"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  £<Notes>
<UUID>cf6aead1-841f-41be-b076-6c9d92c943b2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-EGFP-MCS-6Ã—His-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:13:18">2026.1.13</Created>
<LastModified UTC="3:39:5">2026.3.11</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO ÿþ              E              ÿÿÿÿYô? P                                                                                                                                                             o<StrandColors><TopStrand><ColorRange range="0..1640" colors="black"/><ColorRange range="1641..1652" colors="light blue"/><ColorRange range="1653..6186" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1640" colors="black"/><ColorRange range="1641..1652" colors="light blue"/><ColorRange range="1653..6186" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
